GLP-1
Typical Dosing Protocols (Research/Compounded Use Only) – Semaglutide
Common protocol: Start with 0.25 mg subcutaneously once weekly for the first 4 weeks (titration phase). Increase every 4 weeks as tolerated:
Weeks 5–8: 0.5 mg weekly
Weeks 9–12: 1 mg weekly
Weeks 13–16: 1.7 mg weekly
Maintenance: 2.4 mg once weekly
Other reported ranges:
Milder goals / better tolerance: 0.5–1 mg weekly
Aggressive fat loss: Up to 2.4 mg weekly (standard maintenance dose)
Microdosing: Some start as low as 0.1–0.25 mg with slower titration
Reconstitution example (for research vials, common 5 mg or 10 mg): Add 2 mL bacteriostatic water.
0.25 mg = 0.05 mL (5 units on U-100) at 5 mg/mL concentration
1 mg = 0.2 mL (20 units) at 5 mg/mL concentration
2.4 mg = 0.48 mL (48 units) at 5 mg/mL concentration
Administration: Subcutaneous injection (abdomen, thigh, or upper arm) on the same day each week, with or without food.
Dosing is highly individualized based on goals (weight loss, appetite control, metabolic support), tolerance, and response—consult a qualified healthcare provider experienced with GLP-1 therapies for personalized guidance and monitoring. This is for informational purposes only.
