Mazdutide
KPV (Lysine-Proline-Valine) – Subcutaneous Injection only
Typical daily dose: 200–500 mcg once daily.
Range: Start at 200 mcg; titrate to 300–400 mcg; up to 500 mcg (some protocols 200–1,000 mcg).
Frequency: Once daily.
Reconstitution example (10 mg vial + 3 mL bacteriostatic water ≈ 3.33 mg/mL): – 200 mcg ≈ 6 units (0.06 mL) – 300 mcg ≈ 9 units (0.09 mL) – 400 mcg ≈ 12 units (0.12 mL) – 500 mcg ≈ 15 units (0.15 mL) on U-100 insulin syringe.
VIP (Vasoactive Intestinal Peptide) – Subcutaneous Injection only
Typical dose: 100–200 mcg per injection.
Range: Start 50–100 mcg; standard 100–200 mcg; up to 200–300 mcg (some protocols 400 mcg total daily divided).
Frequency: 1–2 times daily (or 5 times per week in some protocols).
Reconstitution example (5 mg vial + 5 mL bacteriostatic water = 1 mg/mL): – 100 mcg = 10 units (0.1 mL) – 200 mcg = 20 units (0.2 mL) on U-100 insulin syringe.
NAD+ – Subcutaneous Injection only
Typical dose: 50–100 mg per injection.
Range: Start 20–50 mg; standard 50–100 mg; up to 100–200 mg (some protocols reach 120 mg).
Frequency: 2–3 times per week (some start daily for 1 week then reduce to Mon–Fri).
Reconstitution / Concentration example (common 100 mg/mL solution): – 50 mg = 0.5 mL (50 units) – 100 mg = 1.0 mL (100 units) on U-100 insulin syringe.
Mazdutide – Subcutaneous Injection only
Typical maintenance dose: 4–9 mg once weekly (Phase 3 trials commonly use 4 mg, 6 mg, or 9 mg).
Range: 3–9 mg weekly (research explores up to 10–16 mg with extended titration).
Titration (slow escalation): – Weeks 1–4: 1.5–2 mg – Weeks 5–8: 3–4 mg – Weeks 9–12: 4.5–6 mg – Then 6–9 mg (or higher with further steps).
Frequency: Once weekly (same day each week).
Reconstitution example (10 mg vial + 3 mL bacteriostatic water ≈ 3.33 mg/mL): – 4 mg ≈ 120 units (1.2 mL) – 6 mg ≈ 180 units (1.8 mL) – 9 mg ≈ 270 units (2.7 mL) on U-100 insulin syringe.
