Alprostadil
Recommended Dosage
Common wellness/research protocol (Intracavernosal Injection): Start with 2.5–5 mcg injected directly into the corpus cavernosum. Titrate upward in 2.5–5 mcg increments as needed. Most men respond well to 5–20 mcg per use. Do not exceed 40–60 mcg in a single dose.
Other reported ranges:
Standard effective dose: 10–20 mcg per injection
Maximum recommended single dose: 60 mcg (rarely needed)
Frequency: No more than 3 times per week, with at least 24 hours between doses.
Topical Cream (if using compounded formulation): 0.2–0.4% cream applied to the tip of the penis (meatus) approximately 30 minutes before activity. Typical starting amount is a pea-sized amount (≈100–200 mg of cream).
Administration Notes:
Use a fine insulin syringe (30–31 gauge) for injection.
Rotate injection sites (left/right side of penis).
Erection usually begins within 5–15 minutes and lasts 30–60 minutes depending on dose.
Always start low and titrate slowly to find the lowest effective dose.
Dosing is highly individualized based on response, tolerance, and underlying cause of ED—consult a qualified healthcare provider experienced with alprostadil for personalized guidance and proper training on injection technique. This is for informational purposes only.
